ABSTRACT
Complement system is a central part of the innate immune response that has developed as a first defense against non-self cells.Complement activation has traditionally been considered part of the body's immunosurveillance against cancer.However,recent studies have demonstrated that activated components of the complement system can assist the escape of tumor cells from immunosurveillance,promote angiogenesis,activate mitogenic signaling pathways,sustain cellular proliferation and insensitivity to apoptosis,and participate in tumor cell invasion and migration.This review reviewed the progress of complement activation and tumor immune surveillance and immune evasion,in order to provide a new strategy for antitumor immunotherapy.
ABSTRACT
Objective To investigate the therapeutic value of high-resolution microendoscopy for early esophageal cancer.Methods A total of 60 patients,who underwent esophageal endoscopy,were included in this study.The therapeutic value of high-resolution microendoscopy was investigated with reference to pathological results as golden standard.Results Diagnostic sensitivity,specificity,positive predictive value,negative predictive value and accuracy of microendoscopy for high grade dysplasia/early cancer were 81.22％,94.12％,81.82％,94.12％,91.11％,respectively.Diagnosis of severe dysplasia/carcinoma with high-resolution microendoscopy was highly consistent with that of pathology (K =0.760).Conclusion The high-resolution microendoscopy is of high diagnostic value for early esophagus cancer.